The vacuolar fusion regulated by HOPS complex promotes hyphal initiation and penetration in Candida albicans

Abstract excerpt

Abstract The transition between yeast and hyphae is crucial for regulating the commensalism and pathogenicity in Candida albicans . The mechanisms that affect the invasion of hyphae in solid media, whose deficiency is more related to the pathogenicity of C. albicans , have not been elucidated. Here, we found that the disruption of VAM6 or VPS41 which are components of the homotypic vacuolar fusion and protein...

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