Article

Structural determinants of pure antiestrogenicity

2023-11-02

Abstract excerpt

Inhibitory activities of antiestrogens on estrogen receptor alpha (ERα) range from mixed antagonism/agonism (selective ER modulators; SERMs) to complete antiestrogenicity associated with accelerated ERα turnover (selective ER degraders; SERDs). Here, we show using a panel of SERMs, SERDs and a PROTAC that efficient induction of ERα SUMOylation better accounts for complete transcriptional repression than increased...

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Literature Corpus work: ab1b3070-fdc2-58a4-8730-0668732a5389
DOI: 10.1101/2023.10.31.564979

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