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ZD6474 Suppresses Oncogenic RET Isoforms in a <i>Drosophila</i> Model for Type 2 Multiple Endocrine Neoplasia Syndromes and Papillary Thyroid Carcinoma

1 May 2005

Abstract excerpt

Patients with hereditary medullary thyroid carcinoma (MTC) associated with multiple endocrine neoplasia (MEN) types 2A and 2B and familial MTC (FMTC) have mutations in the RET proto-oncogene. Approximately 40 percent of patients with papillary thyroid carcinoma (PTC) typically have either intrachromosomal or extrachromosomal rearrangements that join the promoter and NH(2)-terminal domains of unrelated genes to...

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PMID: 15867345
DOI: 10.1158/0008-5472.can-04-4561

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ZD6474 Suppresses Oncogenic RET Isoforms in a <i>Drosophila</i> Model for Type 2 Multiple Endocrine Neoplasia Syndromes and Papillary Thyroid CarcinomaPMID 15867345Read ↗

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RET cooperates with RB/p53 inactivation in a somatic multi-step model for murine thyroid cancer.Semantic proximity Read ↗

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