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Article

Development of RET Kinase Inhibitors for Targeted Cancer Therapy

1 Jan 2011

Abstract excerpt

RET (Rearranged during Transfection) is a transmembrane tyrosine kinase expressed in central and peripheral nervous system and neural crest-derived cells and acts as a co-receptor of GDNF family neurotrophic factor in complex with GRFα family proteins. RET protein comprises an extracellular portion with four cadherine-like domains and a cysteine- rich region important for intermolecular interactions; a...

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PMID: 21110809
DOI: 10.2174/092986711794088308

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