Article
A transplantable human medullary thyroid carcinoma as a model for RET tyrosine kinase-driven tumorigenesis.
Endocrine-related cancer - 1 Jun 2007
Johanson Viktor, Ahlman Håkan, Bernhardt Peter, Jansson Svante, Kölby Lars, Persson Fredrik, Stenman Göran, Swärd Christina, Wängberg Bo, Stridsberg Mats, Nilsson Ola
Abstract excerpt
Hereditary medullary thyroid carcinoma (MTC) is caused by germline mutations in the RET proto-oncogene, resulting in constitutive activation of the RET tyrosine kinase. A substantial proportion of sporadic MTCs also have RET mutations, making the RET tyrosine kinase a potential therapeutic target in MTC. We have established a transplantable MTC in nude mice from a sporadic human MTC carrying a RET C634R mutation....
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