Article
Evolution of expression of cardiac phenotypes over a 4-year period in the beta-myosin heavy chain-Q403 transgenic rabbit model of human hypertrophic cardiomyopathy.
Journal of molecular and cellular cardiology - 1 May 2004
Nagueh Sherif F, Chen Suetnee, Patel Rajnikant, Tsybouleva Natalia, Lutucuta Silvia, Kopelen Helen A, Zoghbi William A, Quiñones Miguel A, Roberts Robert, Marian A J
Abstract excerpt
Hypertrophic cardiomyopathy (HCM), the most common cause of sudden cardiac death in the young, is characterized by a diverse array of cardiac phenotypes evolving over several decades. We have developed transgenic rabbits that fully recapitulate the phenotype of human HCM and provide for the opportunity to delineate the sequence of evolution of cardiac phenotypes, and thus, the pathogenesis of HCM. We determined...
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