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Article

Graded effects of unregulated smooth muscle myosin on intestinal architecture, intestinal motility and vascular function in zebrafish.

Disease models & mechanisms - 1 May 2016

Abrams Joshua, Einhorn Zev, Seiler Christoph, Zong Alan B, Sweeney H Lee, Pack Michael

Abstract excerpt

Smooth muscle contraction is controlled by the regulated activity of the myosin heavy chain ATPase (Myh11). Myh11 mutations have diverse effects in the cardiovascular, digestive and genitourinary systems in humans and animal models. We previously reported a recessive missense mutation, meltdown (mlt), which converts a highly conserved tryptophan to arginine (W512R) in the rigid relay loop of zebrafish Myh11. The...

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Identifiers

PMID: 26893369
DOI: 10.1242/dmm.023309
PMCID: PMC4892660

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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