Unregulated smooth-muscle myosin in human intestinal neoplasia.

doi:10.1073/pnas.0801213105

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Article

Unregulated smooth-muscle myosin in human intestinal neoplasia.

Proceedings of the National Academy of Sciences of the United States of America - 8 Apr 2008

Alhopuro Pia, Phichith Denis, Tuupanen Sari, Sammalkorpi Heli, Nybondas Miranda, Saharinen Juha, Robinson James P, Yang Zhaohui, Chen Li-Qiong, Orntoft Torben, Mecklin Jukka-Pekka, Järvinen Heikki, Eng Charis, Moeslein Gabriela, Shibata Darryl, Houlston Richard S, Lucassen Anneke, Tomlinson Ian P M, Launonen Virpi, Ristimäki Ari, Arango Diego, Karhu Auli, Sweeney H Lee, Aaltonen Lauri A

Abstract excerpt

A recent study described a recessive ATPase activating germ-line mutation in smooth-muscle myosin (smmhc/myh11) underlying the zebrafish meltdown (mlt) phenotype. The mlt zebrafish develops intestinal abnormalities reminiscent of human Peutz-Jeghers syndrome (PJS) and juvenile polyposis (JP). To examine the role of MYH11 in human intestinal neoplasia, we searched for MYH11 mutations in patients with colorectal...

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Identifiers

PMID: 18391202
DOI: 10.1073/pnas.0801213105
PMCID: PMC2291082

Genes

MYH11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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