Article
Insulin-like growth factor-I supports proliferation of autocrine thymic lymphoma cells with a pre-T cell phenotype.
Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 1990
Gjerset R A, Yeargin J, Volkman S K, Vila V, Arya J, Haas M
Abstract excerpt
We have studied the phenotypic characteristics and growth properties of murine T lymphoma cell lines derived from primary x-ray-induced thymic lymphomas at the earliest stage at which they can be detected, and well before spreading to other organs has occurred. These cell lines serve as model systems for the earliest events in T cell lymphoma induction, before tumor cell progression and spreading to other organs....
Topics
- Animals
- Antigens, CD
- Cell Division
- Growth Substances
- Hematopoietic Stem Cells
- Insulin-Like Growth Factor I
- Interleukins
- Lymphoma, T-Cell
- Mice
- Mice, Inbred C57BL
- Phenotype