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Article

Pharmacokinetic variability of routinely administered bisoprolol in middle-aged and elderly Japanese patients.

Biological & pharmaceutical bulletin - 1 May 2005

Taguchi Masato, Nozawa Takashi, Igawa Akihiko, Inoue Hiroshi, Takesono Chihiro, Tahara Katsutoshi, Hashimoto Yukiya

Abstract excerpt

The nonlinear mixed effects model (NONMEM) was used to analyze the pharmacokinetics of routinely administered bisoprolol in middle-aged and elderly Japanese patients. The subjects consisted of 29 males and 11 females with a mean age of 63.5+/-10.1. Data on the plasma concentration of bisoprolol from 94 blood samples obtained at steady-state following repetitive oral administration were analyzed using the NONMEM...

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PMID: 15863897
DOI: 10.1248/bpb.28.876

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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