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Article

Nonlinear mixed effects model analysis of the pharmacokinetics of routinely administered bepridil in Japanese patients with arrhythmias.

Biological & pharmaceutical bulletin - 1 Mar 2006

Taguchi Masato, Fujiki Akira, Iwamoto Jotaro, Inoue Hiroshi, Tahara Katsutoshi, Saigusa Katsuya, Horiuchi Isao, Oshima Yukari, Hashimoto Yukiya

Abstract excerpt

This study was performed to evaluate variability in the pharmacokinetics of bepridil in 38 Japanese patients with arrhythmias, and to investigate the effects of aprindine as well as CYP2D6 and CYP3A5 polymorphisms on the oral clearance of bepridil. We determined the polymorphic alleles of CYP2D6...

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Share to Anti-Arrhythmia Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2D6

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Share to Data Interpretation, Statistical

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Source

Identifiers

PMID: 16508157
DOI: 10.1248/bpb.29.517

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16508157-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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