Back to search

Article

Stochastic Differential Equations (SDEs) in NONMEM for Probing Population Pharmacokinetic Model Misspecification: Diagnostic Utility, Practical Considerations, and Future Directions

2026-06-01

Abstract excerpt

Population pharmacokinetic (popPK) models are commonly developed using ordinary differential equations (ODEs) to describe deterministic concentration-time profiles, with unexplained variability typically attributed to interindividual variability or residual error. When model misspecification is present, system-level deviations may be absorbed into these conventional variability terms, making the source and magnitu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
927a8287-aa87-57c7-be91-50335ab049ec
DOI
10.64898/2026.05.28.728340
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Stochastic Differential Equations (SDEs) in NONMEM for Probing Population Pharmacokinetic Model Misspecification: Diagnostic Utility, Practical Considerations, and Future DirectionsDOI 10.64898/2026.05.28.728340
Beyond Student’s t: A Systematic Exploration of Heavy-Tailed Residual Densities for Outlier Handling in Population PK ModelingSemantic proximity
Physiologically Based Pharmacokinetic Modeling of Impaired Carboxylesterase-1 Activity: Effects on Oseltamivir DispositionSemantic proximity
Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation.Semantic proximity
A Digital Twin of the Angiotensin II Receptor Blocker Losartan: Physiologically Based Modeling of Blood Pressure RegulationSemantic proximity
Stochastic modeling of systems mapping in pharmacogenomics.Semantic proximity
Population variability in animal health: Influence on dose-exposure-response relationships: Part I: Drug metabolism and transporter systems.Semantic proximity
Pharmacokinetic variability of routinely administered bisoprolol in middle-aged and elderly Japanese patients.Semantic proximity
Population pharmacokinetic modeling and Monte Carlo simulation-based dosing optimization of trimethoprim-sulfamethoxazole in critically ill patients.Semantic proximity
Derivation and theoretical validation of fractional quasi-steady state approximation (fQSSA) for target-mediated drug disposition models with memory effectsSemantic proximity
Enhancing Pharmacometric Modeling with Full Bayesian Inference and Student’s t-Based M3 Censoring: A Simulated Population PK Study on Robust Handling of Outliers and Censored DataSemantic proximity
Pharmacokinetic Modeling and Monte Carlo Simulation to Predict Interindividual Variability in Human Exposure to Oseltamivir and Its Active Metabolite, Ro 64-0802.Semantic proximity
A Hybrid ODE-Neural Network Framework for Modeling and Guiding GLP-1-Mediated Glucose DynamicsSemantic proximity
Select a neighboring publication to make it the new centre.