Article
GG genotype of cyclin D1 G870A polymorphism is associated with increased risk and advanced colorectal cancer in patients in Singapore.
European journal of cancer (Oxford, England : 1990) - 1 May 2005
Hong Yi, Eu Kong Weng, Seow-Choen Francis, Fook-Chong Stephanie, Cheah Peh Yean
Abstract excerpt
Recent studies have implicated cyclin D1 G870A single-nucleotide polymorphism (SNP) in susceptibility to and early onset of colorectal cancers (CRC). We investigated the role of cyclin D1 G870A SNP in Singapore CRC patients without dominant family history by genotyping 254 patients and 101 controls. The risk of cancer for AA individuals was less than half that of GG individuals (odds ratio (OR) 0.41; 95%...
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