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Article

Coumarins are competitive inhibitors of cytochrome P450 1B1, with equal potency for allelic variants.

Pharmacogenetics and genomics - 1 Mar 2005

Mammen Jennifer S, Kleiner Heather E, DiGiovanni John, Sutter Thomas R, Strickland Paul T

Abstract excerpt

OBJECTIVES: Coumarins are naturally occurring chemicals with potential as chemopreventive agents, several with known action on the cytochrome P450 1A family. We examined whether cytochrome P450 1B1 (CYP1B1) was inhibited by coumarins, whether such inhibition was competitive, and whether inhibition varied between common polymorphic variants of this enzyme. METHODS: We tested the inhibition properties of four...

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Identifiers

PMID: 15861043
DOI: 10.1097/01213011-200503000-00007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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