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Article

Vitamin D receptor genotypes influence the success of calcitriol therapy for recurrent vertebral fracture in osteoporosis.

Pharmacogenetics and genomics - 1 Feb 2005

Morrison Nigel A, George Peter M, Vaughan Tanya, Tilyard Murray W, Frampton Chris M, Gilchrist Nigel L

Abstract excerpt

Osteoporosis is a complex multi-factorial disease where environment, diet and genetics play a role in determining susceptibility. Patients with existing vertebral fracture have a heightened risk of further recurrent vertebral fracture. The efficacy of new osteoporosis therapies is often compared to calcium supplementation. 1,25-dihydroxyvitamin D3 (calcitriol) acts through the vitamin D receptor (VDR) and is...

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Source

Identifiers

PMID: 15861036
DOI: 10.1097/01213011-200502000-00008

Genes

VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Vitamin D receptor genotypes influence the success of calcitriol therapy for recurrent vertebral fracture in osteoporosis.PMID 15861036Read ↗

Vitamin D receptor gene variants: implications for therapy.Semantic proximity Read ↗

Association of Vitamin D Receptor (VDR) Gene Polymorphisms with Osteoporotic Vertebral Fracture Risk: A Case-Control Study.Semantic proximity Read ↗

Vitamin D receptor gene and risk of fracture in postmenopausal women: a meta-analysis.Semantic proximity Read ↗

The association between common vitamin D receptor gene variations and osteoporosis: a participant-level meta-analysis.Semantic proximity Read ↗

Vitamin D Receptor Gene Polymorphisms Affect Osteoporosis-Related Traits and Response to Antiresorptive TherapySemantic proximity Read ↗

Vitamin D receptor gene polymorphisms are associated with the risk of fractures in postmenopausal women, independently of bone mineral density.Semantic proximity Read ↗

Promoter and 3'-untranslated-region haplotypes in the vitamin d receptor gene predispose to osteoporotic fracture: the rotterdam study.Semantic proximity Read ↗

Large-scale population-based study shows no evidence of association between common polymorphism of the VDR gene and BMD in British women.Semantic proximity Read ↗

Vitamin D receptor gene BsmI and TaqI polymorphisms and fracture risk: a meta-analysis.Semantic proximity Read ↗

BsmI vitamin D receptor genotypes influence the efficacy of antiresorptive treatments in postmenopausal osteoporotic women. A 1-year multicenter, randomized and controlled trial.Semantic proximity Read ↗

Vitamin D receptor alleles and rates of bone loss: influences of years since menopause and calcium intake.Semantic proximity Read ↗

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