Article
Large-scale population-based study shows no evidence of association between common polymorphism of the VDR gene and BMD in British women.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jan 2006
Macdonald Helen M, McGuigan Fiona E, Stewart Alison, Black Alison J, Fraser William D, Ralston Stuart, Reid David M
Abstract excerpt
UNLABELLED: The VDR is a candidate gene for osteoporosis. Here we studied five common polymorphisms of VDR in relation to calcium intake and vitamin D status in a population-based cohort of 3100 British women, but found no significant association with bone mass, bone loss, or fracture. INTRODUCTION: Population studies of vitamin D receptor (VDR) polymorphisms have produced conflicting results. We performed a...
Topics
- Alleles
- Bone Density
- Calcium
- Female
- Humans
- Middle Aged
- Osteoporosis, Postmenopausal
- Polymorphism, Restriction Fragment Length
- Predictive Value of Tests
- Receptors, Calcitriol
- United Kingdom
- Vitamin D