Article

Recombinant B3 clade enterovirus D68 strains are efficiently rescued in 293T cells and infect human spinal cord organoids

2024-12-20

Abstract excerpt

<h4>ABSTRACT</h4> Enterovirus D68 (EV-D68) is associated with respiratory disease in children. Between 2014 and 2018, biennial EV-D68 outbreaks coincided with peaks of a polio-like neurologic condition called acute flaccid myelitis (AFM). We hypothesized that specific mutations within the currently circulating B3 clade of EV-D68 impacted neurovirulence. However, recovery of these strains from infectious clon...

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Literature Corpus work: 1c80ddfe-adad-57b1-a216-c2b8fad3447b
DOI: 10.1101/2024.12.20.629498

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