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Article

Receptor-independent spread of a highly neurotropic murine coronavirus JHMV strain from initially infected microglial cells in mixed neural cultures.

Journal of virology - 1 May 2005

Nakagaki Keiko, Nakagaki Kazuhide, Taguchi Fumihiro

Abstract excerpt

Although neurovirulent mouse hepatitis virus (MHV) strain JHMV multiplies in a variety of brain cells, expression of its receptor carcinoembryonic antigen cell adhesion molecule 1 (CEACAM 1) (MHVR) is restricted only in microglia. The present study was undertaken to clarify the mechanism of an extensive JHMV infection in the brain by using neural cells isolated from mouse brain. In contrast to wild-type (wt)...

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Identifiers

PMID: 15857995
DOI: 10.1128/JVI.79.10.6102-6110.2005
PMCID: PMC1091713

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