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Article

Lassa virus entry requires a trigger-induced receptor switch

26 Jun 2014

Abstract excerpt

Lassa virus spreads from a rodent to humans and can lead to lethal hemorrhagic fever. Despite its broad tropism, chicken cells were reported 30 years ago to resist infection. We found that Lassa virus readily engaged its cell-surface receptor α-dystroglycan in avian cells, but virus entry in susceptible species involved a pH-dependent switch to an intracellular receptor, the lysosome-resident protein LAMP1....

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PMID: 24970085
DOI: 10.1126/science.1252480

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