Article
Cytochrome P4501A1 polymorphism as a susceptibility factor for breast cancer in postmenopausal Chinese women in Taiwan.
British journal of cancer - 1 Aug 1999
Huang C S, Shen C Y, Chang K J, Hsu S M, Chern H D
Abstract excerpt
The incidence of breast cancer has been greatly increasing in Taiwan over the past two decades. Since cytochrome P4501A1 (CYP1A1) is involved in the metabolism of environmental carcinogens or oestrogen, we hypothesized that CYP1A1 genetic polymorphism may be a susceptibility factor for breast cancer. This hypothesis was evaluated in this case control study of 150 breast cancer patients and 150 healthy controls...
Topics
- Amino Acid Substitution
- Asian People
- Body Mass Index
- Breast Neoplasms
- China
- Contraceptives, Oral
- Cytochrome P-450 CYP1A1
- Estrogen Replacement Therapy
- Exons
- Female
- Genetic Carrier Screening
- Genetic Predisposition to Disease
- Genetic Variation