Article
Correlations between CYP3A4 polymorphism and susceptibility to breast cancer in Chinese Han population.
International journal of clinical oncology - 1 Feb 2019
Liu Xu, Huang Xi, Zhang Shanshan, Niu Fanglin, Ouyang Yongri, Shou Zhexing, Liu Jikui
Abstract excerpt
BACKGROUND: CYP3A4 is a major enzyme catalyzing the metabolism of endogenous steroids that play an important role in the etiology of carcinogenesis. This study was designed to investigate the contribution of CYP3A4 polymorphism to breast cancer in Chinese Han female population. METHODS: To examine whether variants of CYP3A4 contribute to breast cancer, 5 single-nucleotide polymorphisms (SNPs) of CYP3A4 were...
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