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Article

Identification of pigment epithelium-derived factor as a direct target of the p53 family member genes.

Oncogene - 28 Jul 2005

Sasaki Yasushi, Naishiro Yasuyoshi, Oshima Yuichiro, Imai Kohzoh, Nakamura Yusuke, Tokino Takashi

Abstract excerpt

p63 and p73 show a high degree of structural homology to p53 and are members of a family of transcriptional factors that can activate transcription of p53-responsive genes. p53 is mutated in more than 50% of human cancers, whereas p63 and p73 are rarely mutated. Studies of knockout mice also revealed an unexpected functional diversity among the p53 family. To determine how p63 and p73 are involved in...

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Identifiers

PMID: 15856012
DOI: 10.1038/sj.onc.1208695

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification of pigment epithelium-derived factor as a direct target of the p53 family member genes.PMID 15856012Read ↗

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Dissecting the DNA binding landscape and gene regulatory network of p63 and p53Semantic proximity Read ↗

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