Article
The Golgi apparatus of spinal cord motor neurons in transgenic mice expressing mutant Cu,Zn superoxide dismutase becomes fragmented in early, preclinical stages of the disease.
Proceedings of the National Academy of Sciences of the United States of America - 28 May 1996
Mourelatos Z, Gonatas N K, Stieber A, Gurney M E, Dal Canto M C
Abstract excerpt
Dominant mutations of the SOD1 gene encoding Cu,Zn superoxide dismutase have been found in members of certain families with familial amyotrophic lateral sclerosis (ALS). To better understand the contribution of SOD1 mutations in the pathogenesis of familial ALS, we developed transgenic mice expressing one of the mutations found in familial ALS. These animals display clinical and pathological features closely...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.