Article
Antiretroviral activity of didanosine in patients with different clusters of reverse transcriptase mutations.
AIDS (London, England) - 11 Sept 2006
Blanco Jose Luis, Biglia Alejandra, De Lazzari Elisa, Mallolas Josep, Martinez Esteban, Pumarola Tomás, Larrousse María, Milinkovic Ana, León Agathe, Lonca Montserrat, Laguno Montserrat, Gatell Josep María
Abstract excerpt
Patterns of mutations associated with didanosine (ddI) resistance are still a controversial issue. The correlation between different clusters of reverse transcriptase mutations with the short-term virological activity of ddI when added to a failing regimen was examined in 40 patients. The median fall in plasma viral load at week 4 was 0.67 log10 copies/ml. There was good correlation between the median fall in...
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