Article
Novel polymorphisms in the neuropeptide-Y Y5 receptor associated with obesity in Pima Indians.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity - 1 May 2000
Jenkinson C P, Cray K, Walder K, Herzog H, Hanson, Ravussin E
Abstract excerpt
OBJECTIVE: To investigate whether the neuropeptide Y receptor 5 gene (NPY5R) is associated with obesity in humans. DESIGN: The NPY5R gene was screened for polymorphisms by direct sequencing in two groups of Pima Indians, selected for extremes of body mass index (BMI). Genotype frequencies were analyzed for association with BMI extreme. SUBJECTS: Full-heritage Pima Indians, non-diabetic and not first degree...
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