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UV‐induced DNA damage in human keratinocytes: Quantitation and correlation with long‐term survival

25 Apr 2005

Abstract excerpt

Ultraviolet (UV) radiation has a major role in the pathogenesis of skin cancer due to its capacity to induce immunosuppression and DNA damage in cells. In this study, we describe the use of a novel extra-long polymerase chain reaction (XL-PCR) assay for detection of UV-inducible DNA lesions in a human keratinocyte line (HaCaT cells). Ultraviolet B (UVB), in doses from 4 to 50 mJ/cm2 resulted in a linear increase...

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PMID: 15854128
DOI: 10.1111/j.0906-6705.2005.00282.x

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