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5‐aminolevulinic acid photodynamic therapy protects against UVB‐induced skin photoaging: A DNA‐repairing mechanism involving the BER signalling pathway

1 Jul 2024

Abstract excerpt

Low-dose 5-aminolevulinic acid photodynamic therapy (ALA-PDT) has been used to cope with skin photoaging, and is thought to involve DNA damage repair responses. However, it is still unknown how low-dose ALA-PDT regulates DNA damage repair to curb skin photoaging. We established a photoaging model using human dermal fibroblasts (HDFs) and rat skin. RNA-sequencing (RNA-seq) analysis was conducted to identify...

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PMID: 39044341
DOI: 10.1111/jcmm.18536

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