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Article

Amplification of <i>IGH/MYC</i> fusion in clinically aggressive <i>IGH/BCL2</i>‐positive germinal center B‐cell lymphomas

25 Apr 2005

Abstract excerpt

Activation of an oncogene via its juxtaposition to the IGH locus by a chromosomal translocation or, less frequently, by genomic amplification is considered a major mechanism of B-cell lymphomagenesis. However, amplification of an IGH/oncogene fusion, coined a complicon, is a rare event in human cancers and has been associated with poor outcome and resistance to treatment. In this article are descriptions of two...

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Identifiers

PMID: 15852472
DOI: 10.1002/gcc.20187

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

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Amplification of <i>IGH/MYC</i> fusion in clinically aggressive <i>IGH/BCL2</i>‐positive germinal center B‐cell lymphomasPMID 15852472Read ↗

Inferior survival in high-grade B-cell lymphoma with <i>MYC</i> and <i>BCL2</i> and/or <i>BCL6</i> rearrangements is not associated with <i>MYC/IG</i> gene rearrangementsSemantic proximity Read ↗

Complex oncogenic translocations with gene amplification are initiated by specific DNA breaks in lymphocytes.Semantic proximity Read ↗

Identification of <i>IGHC</i>δ–<i>BACH2</i> fusion transcripts resulting from cryptic chromosomal rearrangements of 14q32 with 6q15 in aggressive B‐cell lymphoma/leukemiaSemantic proximity Read ↗

Non-IG::MYC in diffuse large B-cell lymphoma confers variable genomic configurations and MYC transactivation potentialSemantic proximity Read ↗

Translocation–excision–deletion–amplification mechanism leading to nonsyntenic coamplification of <i>MYC</i> and <i>ATBF1</i>Semantic proximity Read ↗

<i>C-MYC, BCL2</i> and <i>BCL6</i> Translocation in B-cell Non-Hodgkin Lymphoma CasesSemantic proximity Read ↗

AID Is Required for the Chromosomal Breaks in c-myc that Lead to c-myc/IgH TranslocationsSemantic proximity Read ↗

Activated mature B cells undergo enforced Sµ-3'RRrec in the λ-c-MYC mouse modelSemantic proximity Read ↗

Long-range oncogenic activation of Igh-c-myc translocations by the Igh 3' regulatory region.Semantic proximity Read ↗

Hodgkin's lymphoma cell lines are characterized by frequent aberrations on chromosomes 2p and 9p including <i>REL</i> and <i>JAK2</i>Semantic proximity Read ↗

Complex Chromosomal Rearrangements in B-Cell Lymphoma: Evidence of Chromoanagenesis? A Case Report.Semantic proximity Read ↗

Role of the translocation partner in protection against AID-dependent chromosomal translocationsSemantic proximity Read ↗

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