Translocation–excision–deletion–amplification mechanism leading to nonsyntenic coamplification of <i>MYC</i> and <i>ATBF1</i>

Abstract excerpt

Despite oncogene amplification being a characteristic of many tumor types, the mechanisms leading to amplicon formation have remained largely unresolved. In this study, we used a combinatorial approach of fluorescence in situ hybridization and single-nucleotide polymorphism chip gene copy number analyses to unravel the mechanism leading to nonsyntenic coamplification of MYC and ATBF1 in SJNB-12 cells. To explain...

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