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Article

A conserved pre-block interaction motif regulates potassium channel activation and N-type inactivation.

PloS one - 1 Jan 2013

Pfaffinger Paul J

Abstract excerpt

N-type inactivation occurs when the N-terminus of a potassium channel binds into the open pore of the channel. This study examined the relationship between activation and steady state inactivation for mutations affecting the N-type inactivation properties of the Aplysia potassium channel AKv1 expressed in Xenopus oocytes. The results show that the traditional single-step model for N-type inactivation fails to...

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Identifiers

PMID: 24236164
DOI: 10.1371/journal.pone.0079891
PMCID: PMC3827413

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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