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Article

The Interplay of Genetic Predisposition, Circadian Misalignment, and Metabolic Regulation in Obesity.

Current obesity reports - 1 Mar 2025

Halder Sajal Kumar, Melkani Girish C

Abstract excerpt

PURPOSE OF REVIEW: This review explores the complex interplay between genetic predispositions to obesity, circadian rhythms, metabolic regulation, and sleep. It highlights how genetic factors underlying obesity exacerbate metabolic dysfunction through circadian misalignment and examines promising interventions to mitigate these effects. RECENT FINDINGS: Genome-wide association Studies (GWAS) have identified...

Read the complete abstract on PubMed

Topics

Humans
Obesity
Genetic Predisposition to Disease
Circadian Rhythm
Sleep
Polymorphism, Single Nucleotide
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Circadian Clocks

Energy Metabolism

Source

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Identifiers

PMID: 40024983
DOI: 10.1007/s13679-025-00613-3
PMCID: PMC11872776

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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