Power and related statistical properties of conditional likelihood score tests for association studies in nuclear families with parental genotypes.

Abstract excerpt

Both population based and family based case control studies are used to test whether particular genotypes are associated with disease. While population based studies have more power, cryptic population stratification can produce false-positive results. Family-based methods have been introduced to control for this problem. This paper presents the full likelihood function for family-based association studies for...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Case-Control Studies
• Share to Genetic Predisposition to Disease