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Article

Control of mitochondrial integrity influences oocyte quality during reproductive aging

18 Aug 2023

Abstract excerpt

Reduced quality in oocytes from women of advanced maternal age (AMA) is associated with dysfunctional mitochondria. The objective of this study was to investigate the mechanisms controlling mitochondrial quality during maternal aging in mouse and human oocytes. We first evaluated the expression of proteins involved in the mitochondrial unfolded protein response (UPRmt) and mitophagy in in vivo matured metaphase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37594790
DOI: 10.1093/molehr/gaad028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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