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Developmental Effects of Sublethal Mitochondrial Injury in Mouse Oocytes1

2 Feb 2006

Abstract excerpt

Mitochondrial dysfunction may be acquired or inherited by oocytes without detectable morphological abnormalities. This pathology may account for some examples of unexplained pregnancy loss in women following transfer of morphologically normal in vitro fertilization (IVF) embryos. The present study was intended to determine whether sublethal mitochondrial injury in mouse oocytes before IVF negatively affects pre-...

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PMID: 16452460
DOI: 10.1095/biolreprod.105.048611

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