Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

SMN-independent subunits of the SMN complex. Identification of a small nuclear ribonucleoprotein assembly intermediate.

The Journal of biological chemistry - 21 Sept 2007

Battle Daniel J, Kasim Mumtaz, Wang Jin, Dreyfuss Gideon

Abstract excerpt

The survival of motor neurons (SMN) complex is essential for the biogenesis of small nuclear ribonucleoprotein (snRNP) complexes in eukaryotic cells. Reduced levels of SMN cause the motor neuron degenerative disease, spinal muscular atrophy. We identify here stable subunits of the SMN complex that do not contain SMN. Sedimentation and immunoprecipitation experiments using cell extracts reveal at least three...

Topics

Adenosine Triphosphate
HeLa Cells
Hot Temperature
Humans
Hydrolysis
Immunoprecipitation
Microscopy, Fluorescence
Nerve Tissue Proteins
Phenotype
RNA Interference
RNA, Small Nuclear

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA-Binding Proteins

Ribonucleoproteins, Small Nuclear

SMN Complex Proteins

Sucrose

Time Factors

Source

Identifiers

PMID: 17640873
DOI: 10.1074/jbc.M702317200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SMN-independent subunits of the SMN complex. Identification of a small nuclear ribonucleoprotein assembly intermediate.PMID 17640873Read ↗

Gemin8 Is a Novel Component of the Survival Motor Neuron Complex and Functions in Small Nuclear Ribonucleoprotein AssemblySemantic proximity Read ↗

Gemins modulate the expression and activity of the SMN complexSemantic proximity Read ↗

A Comprehensive Interaction Map of the Human Survival of Motor Neuron (SMN) ComplexSemantic proximity Read ↗

Emerging Roles of Gemin5: From snRNPs Assembly to Translation ControlSemantic proximity Read ↗

Multiprotein Complexes of the Survival of Motor Neuron Protein SMN with Gemins Traffic to Neuronal Processes and Growth Cones of Motor NeuronsSemantic proximity Read ↗

Spliceosomal small nuclear ribonucleoprotein biogenesis defects and motor neuron selectivity in spinal muscular atrophy.Semantic proximity Read ↗

The Survival of Motor Neurons Protein Determines the Capacity for snRNP Assembly: Biochemical Deficiency in Spinal Muscular AtrophySemantic proximity Read ↗

SMN and Gemins: ‘We are family’ … or are we?Semantic proximity Read ↗

Gemin5 Binds to the Survival Motor Neuron mRNA to Regulate SMN ExpressionSemantic proximity Read ↗

Gemin proteins are required for efficient assembly of Sm-class ribonucleoproteinsSemantic proximity Read ↗

Identification and Characterization of Gemin7, a Novel Component of the Survival of Motor Neuron ComplexSemantic proximity Read ↗

Spinal Muscular Atrophy: From Defective Chaperoning of snRNP Assembly to Neuromuscular DysfunctionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.