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Article

Readthrough of dystrophin stop codon mutations induced by aminoglycosides.

Annals of neurology - 1 Mar 2004

Howard Michael T, Anderson Christine B, Fass Uwe, Khatri Shikha, Gesteland Raymond F, Atkins John F, Flanigan Kevin M

Abstract excerpt

We report the translational readthrough levels induced by the aminoglycosides gentamicin, amikacin, tobramycin, and paromomycin for eight premature stop codon mutations identified in Duchenne's and Becker's muscular dystrophy patients. In a transient transfection reporter assay, aminoglycoside treatment results show that one stop codon mutation is suppressed significantly better (up to 10% stop codon readthrough)...

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Identifiers

PMID: 14991821
DOI: 10.1002/ana.20052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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