Article
The role of cytokine gene polymorphisms in determining disease susceptibility and phenotype in inflammatory bowel disease.
The American journal of gastroenterology - 1 May 2005
Cantor Michael J, Nickerson Peter, Bernstein Charles N
Abstract excerpt
BACKGROUND AND AIMS: Emerging data indicate that alterations in cytokine synthesis may play a role in inflammatory bowel disease (IBD) pathogenesis. The differential production of cytokines has been linked to single nucleotide polymorphisms in gene promoter regions, signal sequences, and gene introns. The aim of this study was to assess the relationship between polymorphisms involving five cytokine genes...
Topics
- Adult
- Codon
- Colitis, Ulcerative
- Crohn Disease
- Cytokines
- Female
- Genetic Predisposition to Disease
- Humans
- Inflammatory Bowel Diseases
- Interferon-gamma
- Interleukin-10
- Interleukin-6
- Introns
- Lymphotoxin-alpha
- Male