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Article

Extremely low penetrance of hearing loss in four Chinese families with the mitochondrial 12S rRNA A1555G mutation.

Biochemical and biophysical research communications - 25 Mar 2005

Young Wie-Yen, Zhao Lidong, Qian Yaping, Wang Qiuju, Li Ning, Greinwald John H, Guan Min-Xin

Abstract excerpt

Mutations in mitochondrial DNA (mtDNA) have been found to be associated with sensorineural hearing loss. We report here the clinical, genetic, and molecular characterization of four Chinese pedigrees with aminoglycoside-induced and nonsyndromic hearing impairment. Clinical evaluation revealed the variable phenotype of hearing impairment including audiometric configuration in these subjects, although these...

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Identifiers

PMID: 15708009
DOI: 10.1016/j.bbrc.2005.01.085

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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