Article
Mannose-binding lectin in severe acute respiratory syndrome coronavirus infection.
The Journal of infectious diseases - 15 May 2005
Ip W K Eddie, Chan Kwok Hung, Law Helen K W, Tso Gloria H W, Kong Eric K P, Wong Wilfred H S, To Yuk Fai, Yung Raymond W H, Chow Eudora Y, Au Ka Leung, Chan Eric Y T, Lim Wilina, Jensenius Jens C, Turner Malcolm W, Peiris J S Malik, Lau Yu Lung
Abstract excerpt
Little is known about the innate immune response to severe acute respiratory syndrome (SARS) coronavirus (CoV) infection. Mannose-binding lectin (MBL), a key molecule in innate immunity, functions as an ante-antibody before the specific antibody response. Here, we describe a case-control study that included 569 patients with SARS and 1188 control subjects and used in vitro assays to investigate the role that MBL...
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