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Article

Functional visualization of viral molecular motor by hydrogen-deuterium exchange reveals transient states.

Nature structural & molecular biology - 1 May 2005

Lísal Jirí, Lam Tukiet T, Kainov Denis E, Emmett Mark R, Marshall Alan G, Tuma Roman

Abstract excerpt

Molecular motors undergo cyclical conformational changes and convert chemical energy into mechanical work. The conformational dynamics of a viral packaging motor, the hexameric helicase P4 of dsRNA bacteriophage phi8, was visualized by hydrogen-deuterium exchange and high-resolution mass spectrometry. Concerted changes of exchange kinetics revealed a cooperative unit that dynamically links ATP-binding sites and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 15834422
DOI: 10.1038/nsmb927

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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