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Article

SUMO-1 modification of PIASy, an E3 ligase, is necessary for PIASy-dependent activation of Tcf-4.

Molecular and cellular biology - 1 May 2005

Ihara Motomasa, Yamamoto Hideki, Kikuchi Akira

Abstract excerpt

We have previously shown that modification of Tcf-4, a transcription factor in the Wnt pathway, with SUMO by PIASy, a SUMO E3 ligase, enhances its transcriptional activity. Since PIASy itself was also modified with SUMO-1, we studied the role of sumoylation of PIASy in the regulation of Tcf-4. Lys(35) was found to be a sumoylation site of PIASy. PIASy(K35R), in which Lys(35) was mutated to Arg, did not enhance...

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Identifiers

PMID: 15831457
DOI: 10.1128/MCB.25.9.3506-3518.2005
PMCID: PMC1084305

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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SUMO-1 modification of PIASy, an E3 ligase, is necessary for PIASy-dependent activation of Tcf-4.PMID 15831457Read ↗

Identification of a new small ubiquitin-like modifier (SUMO)-interacting motif in the E3 ligase PIASy.Semantic proximity Read ↗

Protein inhibitor of activated STAT Y (PIASy) and a splice variant lacking exon 6 enhance sumoylation but are not essential for embryogenesis and adult life.Semantic proximity Read ↗

The 'PINIT' motif, of a newly identified conserved domain of the PIAS protein family, is essential for nuclear retention of PIAS3L.Semantic proximity Read ↗

PIASx Is a Transcriptional Co-repressor of Signal Transducer and Activator of Transcription 4Semantic proximity Read ↗

SUMO modification modulates the transrepression activity of PLZF.Semantic proximity Read ↗

Opposed regulation of corepressor CtBP by SUMOylation and PDZ binding.Semantic proximity Read ↗

SUMO modification of STAT1 and its role in PIAS-mediated inhibition of gene activation.Semantic proximity Read ↗

SUMO modification of repression domains modulates function of nuclear receptor 5A1 (steroidogenic factor-1).Semantic proximity Read ↗

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