Article
Parallel single nucleotide polymorphism genotyping by surface invasive cleavage with universal detection.
Analytical chemistry - 15 Apr 2005
Chen Yan, Shortreed Michael R, Olivier Michael, Smith Lloyd M
Abstract excerpt
Large-scale investigations of sequence variation within the human species will provide information about the basis of heritable variation in disease susceptibility and human migration. The surface invader assay (an adaptation of the invasive cleavage reaction to an array format) is capable of exquisitely sensitive and specific detection of genetic variation. It is shown here that this genotyping technology can be...
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