Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Scoring single-nucleotide polymorphisms at the single-molecule level by counting individual DNA cleavage events on surfaces.

Analytical chemistry - 15 Oct 2005

Nie Bei, Shortreed Michael R, Smith Lloyd M

Abstract excerpt

Single-nucleotide polymorphisms (SNPs) are the most frequent type of human genetic variation. Recent work has shown that it is possible to directly analyze SNPs in unamplified human genomic DNA samples using the surface-invasive cleavage reaction followed by rolling circle amplification (RCA) of the cleavage products. The ability of RCA to produce single-stranded DNA tens of thousands of nucleotides in length...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA
Share to Gene Frequency
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Human

Share to Nucleic Acid Amplification Techniques

Share to Nucleotides

Share to Sensitivity and Specificity

Share to Surface Properties

Source

Identifiers

PMID: 16223245
DOI: 10.1021/ac051025p

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Scoring single-nucleotide polymorphisms at the single-molecule level by counting individual DNA cleavage events on surfaces.PMID 16223245Read ↗

Quantitative detection of individual cleaved DNA molecules on surfaces using gold nanoparticles and scanning electron microscope imaging.Semantic proximity Read ↗

Surface amplification of invasive cleavage products.Semantic proximity Read ↗

Structure-specific DNA cleavage on surfaces.Semantic proximity Read ↗

Genotyping single nucleotide polymorphisms directly from genomic DNA by invasive cleavage reaction on microspheres.Semantic proximity Read ↗

Invasive cleavage reactions on DNA-modified diamond surfaces.Semantic proximity Read ↗

Surface invasive cleavage assay on a maskless light-directed diamond DNA microarray for genome-wide human SNP mapping.Semantic proximity Read ↗

Parallel single nucleotide polymorphism genotyping by surface invasive cleavage with universal detection.Semantic proximity Read ↗

Rolling circle amplification for scoring single nucleotide polymorphisms.Semantic proximity Read ↗

Visualization of oligonucleotide probes and point mutations in interphase nuclei and DNA fibers using rolling circle DNA amplification.Semantic proximity Read ↗

Ligation-mediated rolling-circle amplification-based approaches to single nucleotide polymorphism detection.Semantic proximity Read ↗

Molecular beacon-style hybridization assay for quantitative analysis of surface invasive cleavage reactions.Semantic proximity Read ↗

High accuracy genotyping directly from genomic DNA using a rolling circle amplification based assay.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.