Article
Ultrastructural characterization of maturation, platelet release, and senescence of human cultured megakaryocytes.
The Anatomical record - 1 Jan 2000
Falcieri E, Bassini A, Pierpaoli S, Luchetti F, Zamai L, Vitale M, Guidotti L, Zauli G
Abstract excerpt
The aim of this study was to evaluate the ultrastructural features of human megakaryocytes cultured in vitro. For this purpose, pluripotent CD34(+) (cluster of differentiation 34) hematopoietic progenitor cells, obtained from the peripheral blood of healthy adult donors, were differentiated along the megakaryocytic lineage in liquid cultures by the addition of the megakaryocyte-specific growth factor...
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