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Article

PAK4 mediates morphological changes through the regulation of GEF-H1.

Journal of cell science - 1 May 2005

Callow Marinella G, Zozulya Sergey, Gishizky Mikhail L, Jallal Bahija, Smeal Tod

Abstract excerpt

Precise spatial and temporal regulation of Rho GTPases is required in controlling F-actin-based changes in cell morphology. The molecular mechanisms through which microtubules (MTs) modulate the activity of RhoGTPases and regulate the actin cytoskeleton are unclear. Here we show that p21-activated-kinase 4 (PAK4) mediates morphological changes through its association with the Rho-family guanine nucleotide...

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Share to Biotinylation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15827085
DOI: 10.1242/jcs.02313

Genes

PAK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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