Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TRAF2 is essential for TNF-alpha-induced osteoclastogenesis.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 May 2005

Kanazawa Kiyoshi, Kudo Akira

Abstract excerpt

UNLABELLED: TRAF2-deficient mice show embryonic lethality, and we developed a new in vitro differentiation system to show the function of TRAF2 in osteoclastogenesis, in which osteoclast progenitors are derived from the fetal liver of TRAF2-deficient mice. Using this system, we showed that TRAF2 is required for TNF-alpha-induced osteoclastogenesis. INTRODUCTION: TNF receptor-associated factor 2 (TRAF2) is a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Resorption
Share to Macrophage Colony-Stimulating Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MAP Kinase Kinase 4

Share to NFATC Transcription Factors

Share to Osteoclasts

Share to RANK Ligand

Share to Receptor Activator of Nuclear Factor-kappa B

Share to TNF Receptor-Associated Factor 2

Source

Identifiers

PMID: 15824857
DOI: 10.1359/JBMR.041225

Genes

TRAF2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TRAF2 is essential for TNF-alpha-induced osteoclastogenesis.PMID 15824857Read ↗

FHL2 inhibits the activated osteoclast in a TRAF6-dependent mannerSemantic proximity Read ↗

Severe osteopetrosis, defective interleukin‐1 signalling and lymph node organogenesis in <i>TRAF6</i>‐deficient miceSemantic proximity Read ↗

Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription.Semantic proximity Read ↗

A RANK/TRAF6-dependent signal transduction pathway is essential for osteoclast cytoskeletal organization and resorptive function.Semantic proximity Read ↗

Transcriptional program of mouse osteoclast differentiation governed by the macrophage colony-stimulating factor and the ligand for the receptor activator of NFkappa B.Semantic proximity Read ↗

Early embryonic lethality caused by targeted disruption of the TRAF-interacting protein (TRIP) gene.Semantic proximity Read ↗

TRAF2 deficiency results in hyperactivity of certain TNFR1 signals and impairment of CD40-mediated responses.Semantic proximity Read ↗

T2BP, a novel TRAF2 binding protein, can activate NF-kappaB and AP-1 without TNF stimulation.Semantic proximity Read ↗

Large Scale Gene Expression Analysis of Osteoclastogenesisin Vitro and Elucidation of NFAT2 as a Key RegulatorSemantic proximity Read ↗

RANK‐mediated amplification of TRAF6 signaling leads to NFATc1 induction during osteoclastogenesisSemantic proximity Read ↗

Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiationSemantic proximity Read ↗

Identification and characterization of Xenopus laevis homologs of mammalian TRAF6 and its binding protein TIFA.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.