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Article

FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner

22 Sept 2005

Abstract excerpt

TNF receptor-associated factor 6 (TRAF6) associates with the cytoplasmic domain of receptor activator of NF-kappaB (RANK). This event is central to normal osteoclastogenesis. We discovered that TRAF6 also interacts with FHL2 (four and a half LIM domain 2), a LIM domain--only protein that functions as a transcriptional coactivator or corepressor in a cell-type--specific manner. FHL2 mRNA and protein are...

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PMID: 16184196
DOI: 10.1172/jci24921

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