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Article

Targeted deletion of the chicken beta-globin regulatory elements reveals a cooperative gene silencing activity.

The Journal of biological chemistry - 17 Jun 2005

Wang Jin, Liu Hui, Lin Chi Mei, Aladjem Mirit I, Epner Elliot M

Abstract excerpt

The chicken beta-globin locus represents a well characterized system to study the role of both proximal and distal regulatory elements in a eukaryotic multigene domain. The function of the chicken beta(A)/epsilon-intergenic enhancer and upstream regulatory elements 5'-HS1 and 5'-HS2 were studied using a gene targeting approach in chicken DT40 cells followed by microcell-mediated chromosome transfer into human...

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PMID: 15824098
DOI: 10.1074/jbc.M501161200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Targeted deletion of the chicken beta-globin regulatory elements reveals a cooperative gene silencing activity.PMID 15824098Read ↗

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