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Article

hnRNP A1 and the SR proteins ASF/SF2 and SC35 have antagonistic functions in splicing of beta-tropomyosin exon 6B.

The Journal of biological chemistry - 10 Sept 2004

Expert-Bezançon Alain, Sureau Alain, Durosay Patrice, Salesse Roland, Groeneveld Herman, Lecaer Jean Pierre, Marie Joëlle

Abstract excerpt

Mutually exclusive splicing of exons 6A and 6B from the chicken beta-tropomyosin gene involves numerous regulatory sequences. Previously, we identified a G-rich intronic sequence (S3) downstream of exon 6B. This element consists of six G-rich motifs, mutations of which abolish splicing of exon 6B. In this paper, we investigated the cellular factors that bind to this G-rich element. By using RNA affinity...

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PMID: 15208309
DOI: 10.1074/jbc.M405377200

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hnRNP A1 and the SR proteins ASF/SF2 and SC35 have antagonistic functions in splicing of beta-tropomyosin exon 6B.PMID 15208309Read ↗

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