Analysis of flavivirus envelope proteins reveals variable domains that reflect their antigenicity and may determine their pathogenesis.

doi:10.1016/0168-1702(94)00090-y

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Article

Analysis of flavivirus envelope proteins reveals variable domains that reflect their antigenicity and may determine their pathogenesis.

Virus research - 1 Mar 1995

Gritsun T S, Holmes E C, Gould E A

Abstract excerpt

Studies on the molecular basis of flavivirus neutralisation, attenuation and tropism indicate that amino acid substitutions, in different parts of the envelope gene, may be responsible for the altered phenotypes. However, the association of particular substitutions with individual characteristics...

Topics

Amino Acid Sequence
Flavivirus
Genetic Variation
Molecular Sequence Data
Sequence Homology, Amino Acid
Viral Envelope Proteins

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