Article
Analysis of flavivirus envelope proteins reveals variable domains that reflect their antigenicity and may determine their pathogenesis.
Virus research - 1 Mar 1995
Gritsun T S, Holmes E C, Gould E A
Abstract excerpt
Studies on the molecular basis of flavivirus neutralisation, attenuation and tropism indicate that amino acid substitutions, in different parts of the envelope gene, may be responsible for the altered phenotypes. However, the association of particular substitutions with individual characteristics has proven difficult. Comparative analysis of all known tick-borne flavivirus envelope proteins through sequence...
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